Ahead of the show’s mid-season premiere, Vulture ranked all of the friendships forged in the halls of Grey Sloan, from worst to best. Andrew De Luca (Giacomo Gianniotti) and Jo Wilson (Camilla Luddington)Poor, sweet, dumb De Luca. Teddy Altman (Kim Raver) and Owen Hunt (Kevin Mc Kidd)Should Teddy and Owen even be on this list? April wasted her talent for unlikely friendships on this dude. Jo Wilson and Stephanie Edwards Ugh, Stephanie deserves so much better than Jo. Knight) and Lexie Grey (Chyler Leigh)Two dorks obsessed with getting Meredith to like them at one time or another, these two seemed poised to be BFFs. This friendship ends in the most horrible way imaginable.A note: If you don’t see a certain pairing, it’s because they were deemed more of a romance (Mer and Der were never friends), a mentorship (Bailey loves Alex, but they’d never hang), or a sibling relationship (Derek and Lexie were cute, but he was a big brother first). After trying to be chivalrous by helping a very drunk, very sad Jo, he would up getting his face pummeled — and she did basically nothing to help the situation. De Luca still wants to be friends with this trainwreck of a human being. Sure, they claimed they were friends over and over again, but someone was always having The Feelings. Stark (Peter Mac Nicol)This got real creepy, real fast. Case in point: While Steph was grieving her loss of Wilmer Valderrama, Jo just got drunk and cried over her deteriorating relationship with Alex. Alas, Lexie had to go and get a big crush on the guy and ruin everything. But seriously, in what world would Terrible Reed and Farm Girl April ever be best friends? Cristina Yang (Sandra Oh) and April Kepner The only thing that held this relationship together was Cristina applauding April’s turn as the Runaway Bride. Alex Karev (Justin Chambers) and Jackson Avery (Jesse Williams)These two have come a long way since the days of Jackson slugging Alex for being a top-notch jerk to April. Later, he pursues a 'forbidden' relationship with Dr. is a fictional surgeon from the ABC medical drama television series Grey's Anatomy, portrayed by Eric Dane. Sloan is an attending specializing in plastic surgery. Sloan earned the nickname “Mc Steamy” for his good looks by the female interns of Seattle Grace later Seattle Grace Mercy West Hospital. Derek Shepherd, a fellow physician at Seattle Grace, but was the catalyst for the end of Shepherd's marriage when Shepherd caught Sloan sleeping with his wife, Addison.We know how she feels about Amelia, while her relationship with dear, departed Lexie always seemed to stay in the big sister–little sister lane, Meredith and Maggie genuinely seem to enjoy each other and would probably still be buds without the Ellis Grey (Kate Burton) connection.Unfortunately, this easy bond makes the fact that Meredith has been lying to Maggie about hooking up with Riggs much, much worse. Derek Shepherd and Richard Webber (James Pickens Jr.)Oof, talk about a rocky relationship. Derek Shepherd and Owen Hunt Compared to Preston Burke, Derek and Owen bonding over their Twisted Sisters was much more believable.Equally important, however, is the epic friendship between Meredith and Cristina Yang.
Derek explains that Mark had an affair with his wife, Addison (Kate Walsh) while they were living in New York.Because of The Feelings, they were always pretty terrible to one another. The Replacement Interns: Jo, Stephanie (Jerrika Hinton), Leah, Shane (Gaius Charles), and Heather (Tina Majorino)These guys clearly disliked each other, but still, for some reason, continued to eat lunch together. Leah is mostly to blame, but none of them are innocent. Even worse: Jo recognized that she was being a terrible friend, but continued to be extremely terrible. Meredith Grey (Ellen Pompeo) and Tequila This is a one-sided, parasitic friendship and Tequila should stand up for itself, but damn if those two don’t have fun together. Derek Shepherd (Patrick Dempsey) and Preston Burke (Isaiah Washington)Did these guys ever actually like each other? Even she admitted that she was a terrible friend to George, completely cutting him out of her life once he spurned her romantic feelings. The show attempted to explain it — Reed looked genuinely sad when she turned in April for forgetting to check that mom’s airway after a big fire — but still, no. Maggie Pierce (Kelly Mc Creary) and Amelia Shepherd (Caterina Scorsone)One of the many pairings brought together by Meredith, but it seems as though Maggie might be the one person at Grey Sloan who genuinely enjoys Amelia’s presence. Now, they seem to be friends because they’re the last two dudes from their residency group.I mean, trying to get your friend fired to save your marriage? They never bonded like the original five, plus they were pretty mean to Heather. Stephanie is Cristina 2.0 and she deserves a Meredith. They were the top two surgeons at Seattle Grace for a hot minute, and they loved a pair of complicated best friends. In short, there needed to be more hugging to make this friendship believable. George deserved better — that dude jumps in front of buses for strangers! I doubt they would be friends if they didn’t work together, but every guy needs another guy’s shoulder to cry on sometimes. Meredith Grey and Maggie Pierce Meredith hasn’t been friends with all of her sisters.Undeterred, Mark sells his successful private practice (which he previously shared with Derek) and takes over the plastics program at Seattle Grace Hospital.During Meredith's morphine rampage, Mark finds out about his nickname Mc Steamy which was given to him by her during his first trip to Seattle back when he attempted to get Addison back and earn Derek's friendship back.
Mark travels to Seattle, intent on convincing Addison to return with him, but his offer is rejected and Derek declines to renew their friendship.